Cytomegalovirus Overview

Cytomegalovirus Overview 1. unocompromised host Cytomegalovirus is a significant opportunistic pathogen in immuno-compromised patients. Primary infection, reactivation of latent virus, and reinfection are possible and are often clinically silent. The onset of infection is marked by spiking pyrexia, which may resolve in a few days. Its severity is parallel with the level of immunosuppression, and is greatest in bone marrow transplant (BMT) recipients and AIDS patients with low CD4+ T-cell counts. Solid organ transplant recipients, patients receiving immunosuppressive chemotherapy, and subjects with congenital immunodeficiencies may also be symptomatic (Landolfo et al., 2003). Organ transplantation Cytomegalovirus is one of the most important pathogens that infect (SOT) recipients and is associated with increased morbidity and mortality (Beam and Razonable, 2012). Solid organ transplant recipients are particularly susceptible to CMV-related disease due to the immunosuppression necessary to prevent organ rejection. Patients receiving T-cell depleting therapies are at the highest risk The major risk factor for CMV pneumonia is a CMV-seronegative transplant recipient receiving a CMV-seropositive organ. Because of the multiple human strains of CMV, seropositive organ recipients are at risk of re-infection with a different strain of virus. The clinical syndrome is then usually less severe than in primary infection and the onset of disease is often delayed to approximately 6-8 weeks post-transplantation (Alexopouloset al., 2012). Clinical signs of HCMV infection in transplant recipients may be absent or severe, although severe infection is now less frequent as a result of better prophylaxis. HCMV is initially localized in the transplanted organ, but then spreads throughout the gastrointestinal tract and to the retina, skin, endometrium, lungs, and CNS. HCMV disease is more difficult to treat in BMT compared with SOT recipients, and HCMV pneumonia has a high mortality rate, despite the recent introduction of specific antiviral drugs (Landolfo et al., 2003). Lastly, an immunosuppressive syndrome often related to HCMV infection in the late post-transplant period is characterized by superinfection with bacteria, fungi, and protozoa, perhaps due to disturbance of both the humoral and cellular immune response by HCMV (Landolfo et al., 2003). Cytomegalovirus and HIV infection CMV can cause very serious infection in HIV infection (Barrett et al., 2012). Retinitis: Retinitis is the most common manifestation of CMV disease in HIV positive patients. It presents with decreased visual acuity, floaters, and loss of visual fields on one side. It begins as a unilateral disease, but in many cases it progresses to bilateral involvement. It may be accompanied by systemic CMV disease. (Barrett et al., 2012). CMV pneumonia in patients who are HIV positive is uncommon. The reason for this is unknown (Barrett et al., 2012). Gastrointestinal tract: In the upper gastrointestinal tract, CMV has been isolated from oesophageal, gastric and duodenal ulcers. Patients with oesophageal disease may present with painful dysphagia. In the lower gastrointestinal tract, patients with CMV may present with diarrhoea due to colitis (Barrett et al., 2012). CMV may cause disease in the peripheral and central nervous system (Barrett et al., 2012). Replication in the CNS of AIDS patients produces some of the symptoms observed in congenital infection, and is often followed by encephalopathy (Landolfo et al., 2003). Laboratory Diagnosis It is difficult to diagnose CMV infection in immunocompromised patients as it requires not only detection of virus but also determining whether CMV is causing disease. CMV shedding and viremia are common in patients with impaired cellular immunity even when disease due to CMV is not present (Jahan, 2010). Rapid and sensitive technique for diagnosis of CMV infection is of vital importance for the management of immunocompromised patients. A number of rapid and sensitive methods have been developed. These includes DNA probe techniques (Spector and Vacqier, 1983) , Polymerase chain reaction (PCR) (Zipeto et al., 1992), CMV antigen detection in biopsies and bronchoalveolar lavage (Emanuel et al., 1986) and immunofluorescence technique for detection of CMV early antigens in cell (Vander et al., 1988). Moreover, an assay has been developed for CMV antigenemia based on the detection of CMV immediate early antigen (pp65 ) in circulating leucocytes (Boeckh et al., 1996). Histopathology: Histopathology remains the reference standard for diagnosis of tissue-invasive CMV disease (Razonable and Hayden, 2013). CMV infection is indicated by cellular and nuclear enlargement (cytomegalic cells) and the presence of amphophilic to basophilic cytoplasmic inclusions (aggregates of CMV nucleoproteins that are produced during viral replication) (Eid et al., 2010). The severity of CMV infection can be assessed based on the degree of histological involvement (Mattes et al., 2000). While these histopathologic findings are highly characteristic of CMV infection (Mattes et al., 2000), atypical features may be present and may overlap in appearance both with reactive changes and with inclusions of other intracellular viruses. Hence, the diagnosis can be confirmed further by in situ hybridization (ISH) or immunohistochemical (IHC) testing (Razonable and Hayden, 2013). The ISH uses CMV-specific cDNA probes that bind to viral DNA in the cellular materialÂÂ   (Razonable and Hayden, 2013). Likewise, IHC uses monoclonal or polyclonal antibody against early CMV antigen (ChemalyÂÂ   et al., 2004 Histopathology requires an invasive procedure to obtain tissue samples for testing (Eid et al., 2010). As a result, clinicians are often hesitant to perform it. Moreover, repeated biopsies cannot be performed serially to assess the response to treatment (Eid et al., 2010). Accordingly, many clinicians rely on the demonstration of CMV in the peripheral blood by Nucleic acid amplification testing (NAT) or antigen testing to support the clinical diagnosis of tissue-invasive CMV disease in patients with compatible clinical signs and symptoms (Razonable and Humar, 2013). Serology: Serology relies on the sensitive detection of antibodies against CMV in the blood (Vauloup-Fellous et al., 2013). CMV immunoglobulin M (CMV-IgM) is initially secreted during early CMV infection, and the detection of CMV-IgM by serologic assays is indicative of active, acute, or recent infection. Weeks into the course of primary infection, CMV-IgG antibody is secreted, and this antibody persists for life. The detection of CMV-IgG is indicative of previous or past infection (Vauloup-Fellous et al., 2013). Many different assays have been described and evaluated for the detection of CMV IgG antibodies. Among these are complement fixation, ELISA, anticomplement immunofluorescence, radioimmunoassay, and indirect hemagglutination (Ross et al., 2011). Many different assays are available for IgM detection, but enzyme-linked immunosorbent assays (ELISAs) are the most widely used. Recombinant IgM assays using recombinant HCMV proteins and peptides have been developed in an attempt to standardize serological assays. However, studies have shown poor correlation of results obtained with different commercial kits for IgM testing. In addition, assays for IgM antibody lack specificity for primary infection because of false-positive results, because IgM can persist for months after primary infection, and because IgM can be positive in reactivated CMV infections (Ross et al., 2011). Because of the limitations of the IgM assays, IgG avidity assays are utilized in some populations to help distinguish primary from non-primary CMV infection. These assays are based on the observation that IgG antibodies of low avidity are present during the first few months after the onset of infection and avidity increases over time reflecting maturation of the immune response. Thus, high anti-CMV IgG avidity represents longstanding infection in an individual. Avidity levels are reported as the avidity index which is the percentage of IgG bound to the antigen following treatment with denaturing agents (Ross et al., 2011). Seroconversion remains a reliable means of diagnosing primary CMV infection but usually practical only for closely monitored patients such as transplant recipients, for whom pre and post infection sera are readily available (ONeill et al., 1988 and Pass et al., 1983). Culture: This is highly specific for the diagnosis of CMV infection (Razonable and Humar, 2013). Culture can be performed using the conventional plaque assay or the more rapid shell vial centrifugation culture system (Razonable et al., 2002). Isolation of CMV from most clinical samples (other than urine, saliva, and stool) is highly predictive of the diagnosis of CMV disease or the risk of progression from CMV infection into clinical illness (Razonable et al., 2002). In contrast, the use of urine, saliva, and stool samples for CMV culture is of limited clinical utility because viral shedding may be detected in these specimens in CMV-seropositive patients even in the absence of clinical illness (Razonable and Humar, 2013). For CMV-seronegative patients (seen most commonly in pediatric age groups), however, the isolation of CMV in urine (and other samples) may be clinically relevant, since it is suggestive of active primary infection (instead of shedding) (Razonable and Humar, 2013). The major drawbacks to viral culture are its low to modest sensitivity and long turnaround time (Razonable et al., 2002). Accordingly, the clinical use of viral culture is minimal in the contemporary era, when molecular assays are most commonly used in the clinical setting (Razonable et al., 2002). The remaining major clinical use of viral culture is in the diagnosis of CMV infection by use of samples that have not been validated or optimized for molecular testing (Razonable and Humar, 2013). Viral culture may also be required when phenotypic antiviral drug resistance testing is needed, although advances in molecular genotypic assays have emerged for detecting antiviral drug resistance (Hakki and Chou, 2011). Antigen Testing: CMV antigen detection in the blood is the most commonly used phenotypic method for the rapid and sensitive diagnosis of CMV infection (Razonable and Humar, 2013). CMV antigenemia assay uses monoclonal antibodies to detect the CMV pp65 antigen that is expressed in CMV-infected leukocytes during the early phase of the CMV replication process (Razonable et al., 2002). The result of the test is reported as the number of positive cells per total number of cells counted (Razonable and Humar, 2013). Because pp65 is secreted during viral replication, its detection in peripheral blood leukocytes generally signifies active CMV infection. The CMV antigen assay is a rapid and easy test to perform and has a higher sensitivity than that of virus culture (Razonable and Hayden, 2013). It is able to detect CMV infection earlier than virus culture, with some studies reporting the detection of antigenemia an average of 5 to 14 days before the onset of CMV disease (Razonable and Hayden, 2013). Thus, it can be used to detect early CMV replication and to guide the initiation of preemptive therapy (Singh, 2001). In general, the degree of pp65 antigenemia correlates with the risk of subsequent CMV disease. However, there is a lack of consensus as to the threshold of pp65-positive cells that should trigger the initiation of antiviral therapy (Razonable and Hayden, 2013). In some studies, the sensitivity of pp65 antigenemia testing for the diagnosis of CMV infection was comparable to that of CMV NAT by PCR (Garrigue et al., 2006). One of these studies reported a strong correlation between pp65 antigenemia and CMV PCR performed on whole-blood specimens (Garrigue et al., 2006). Other studies, however, have reported a significantly lower sensitivity of antigenemia testing than those of molecular tests (Pang et al., 2009). Moreover, the plasma PCR assay detected CMV infection 12 days earlier than the antigenemia test (Hadaya et al., 2003). The disadvantages of CMV antigenemia testing are its labor-intensive and manual nature. The interpretation of the test is subjective, and there is limited interlaboratory standardization of thresholds of positive cell counts to guide various clinical actions (Razonable et al., 2002). Blood samples being subjected to pp65 antigenemia testing should be processed rapidly (ideally within 6 h) to optimize sensitivity, since test results depend on the life span of leukocytes ex vivo. Delays in the processing of a sample for longer than 24 h may lead to a significant decrease in the number of detectable pp65-positive cells in the blood (Razonable and Hayden, 2013).

Morality Essays -- essays research papers

Morality: An essential to life   Ã‚  Ã‚  Ã‚  Ã‚  A Russian born American science-fiction writer and biochemist once quoted, â€Å"Never let your sense of morals get in the way of doing what’s right.† This statement generates a series of controversial questions. What is right? How do morals affect people and society in which we live? Does everyone have specific morals by which they try to live their life? How does someone realize what their morals are? What are morals? These questions cannot be truthfully answered because everyone has their own definition of what is right and what is wrong and how one should live their life. My definition of morality is the concern with the distinction between good and evil or right and wrong, which can be seen through someone’s actions based on their ethical principles. That is, if someone lives their life based on their morals. Morality plays an important role in your life and the lives of others whether or not you live with it or not.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  From the time when I was little, I thought I’ve always had a good idea about what is right and what is wrong. I’m not saying I always did the proper thing, but each time I did something morally indecent or offensive, my conscience always let me know. Over time, incidents where my morality was tested have helped me develop a number of morals in which I try to live my life. I believe having morals is an important part of a developing character....

Alone Together: Why We Expect More from Technology Essay

The day and the life of a teenagers, is consumed with text messages, Face time, Instagram, Twitter, YouTube, and Face book messages. Many of us watch TV, listen to music, and â€Å"live chat† with our friends by way of the â€Å"smart phone†. I’m sure our parents wished for once, we would â€Å"look up† from our phones and have an actual conversation with them, but we can’t. We’re addicted to our phones. And sadly, this is typical living for modern people to â€Å"deal with† this hurried and fast-paced society. Nevertheless, it seems that we have less and less time to face the real world around as â€Å"technology† owns us. Is this new form of communication doing us good or bad? In chapter eight of the book â€Å"Alone Together: Why We Expect More from Technology and Less from Each Other,† the author Sherry Turkle, emphasize that people prefer technology over face-to-face communication and therefore, as known as â€Å"cy borgs†. It seems impossible for people to a moment without technological devices such as webcams, cell phones or laptops. We love the ideal of staying connected with others by way of our handheld or lap devices. As stated by the author, â€Å"cyberspace† offer teenagers a place to create and explore identity. Additionally, virtual communities, such as the internet, allow us a chance at forming a â€Å"Second Life†. By creating an avatar, we can edit our lives as we know it by creating a profile that will attract â€Å"followers, friend requests, and likes†. We literally have our relationships in the â€Å"palm† of our hands. But, is this real? Can we sustain these types of relationships? As noted in the chapter, â€Å"Virtual places offers connection with uncertain claims to commitment†¦People talk about digital life as the â€Å"place for hope,† the place where something new will come to them† (Turkle 153). I can admit to checking my phone just about every 5 minutes for a new pictures or messages from my â€Å"friends†. Social media provides instant updates and allow us to stay attune with what’s happening in the world – my world. However, Turkle’s stance remains neutral, yet depicts both the advantages and disadvantages being tethered to the internet gives us. We tend to remove ourselves from society by talking on phones or glancing down at screens of their mobile devices. We â€Å"log out† of the â€Å"real world† and â€Å"log in† the virtual space and therefore, cease the interaction or human connection with people surrounding us. In Chapter 1, Turkle states â€Å"†¦Whether or not our devices are in use, without them we feel  disconnected, adrift. Gradually, we come to see our online life as life itself. †¦ Technology reshapes the landscape of our emotional lives, but is it offering the lives we want to lead?† (16, 17). We’re unable to live without technology. We have conditioned ourselves to never leave home without our devices . Gone are the days of remember important contact information. Our handheld device house all of this information, so should we lose the smart phone, we’re completely lost. Moreover, people feel like their abilities are enhanced and efficiency are increased while multitasking. As noted in chapter 8, â€Å"†¦We have moved from multitasking to multi-lifing.† (160). In fact, we’re unable to perform basic tasks without some form of technological device near us – streaming music, TV, or live chats. It seems that we gain more time from the technological devices than we gain from picking up the phone or having a face-to-face meeting. Turkel, stated, â€Å"The online life may be enjoyable and fulfilling, making one even less satisfied with life at home. Networked, we are together, but so lessened are our expectations of each other that we can feel utterly alone. And there is the risk that we come to see others as objects to be accessed–and only for the parts we find useful, comforting, or amusing.† (154). Our expectations have â€Å"dimmed† due to our reliance on text messages, emails, and other social media outlets. We accept cryptic messages instead of organized, well throughout communications or agenda. Is there such a thing as social media overload? Can we escape from our devices long enough to simply â€Å"breathe†? One of the examples from the book, a museum curator Diane, she can barely keep up with the pace of technology. It’s her goal to remain â€Å"offline† in order to enjoy her life during her scheduled vacation and not feel inclined to response to the â€Å"unread† messages. The author suggests to us that in order to have more time to think, we have to the networked devices away, especially our youth. The author, Sherry Turkle, does not clearly express whether she encourage or discourages the use of networked devices, however, through her words, we can see that she implies that it is important for that we take a break from the virtual world and try to get back to the basics. As for my opinion, I enjoy my smart phone and the access that I have, however, realize after reading this book, I need to develop â€Å"real† friendships and not rely on my â€Å"followers† on the popular social media outlets to bring me instant gratification. However, I agree  with the author, people have a hard time relaxing because we’re always â€Å"on† and in receipt of news, be it good or bad. Yet, I choose the virtual world. Works Cited Turkle, Sherry. Alone Together: Why We Expect More from Technology and Less from Each Other. New York: Basic Books, 2011. Print.

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Major League Baseball Industry Overview, Key Issues and...

The MLB: Major League Baseball is the highest level of baseball play in the United States. It is comprised of two leagues, the National League and the American League, and 30 separate teams who each play a 162 game season. The commissioner of the league is Bud Selig, as commissioner he oversees the logistics of organizing the umpiring employees, and all contracts dealing with labor, marketing and TV broadcasting. Mostly funded by private enterprises, with partial funding from public taxes; the MLB as a whole brought in $132 million in 2005 of operating income, which jumped to $360 million of in 2006 (Orzanian). The overlapping schedules make the National Football League the most competition the MLB has for viewers. Key Issues: In 1994,†¦show more content†¦They are devoted to contributing to the betterment of society through philanthropy, charities and organizations. Lastly, they strive to provide affordable entertainment to the global market. SWOT Analysis: STRENGTHS: Market Location: The Red Sox have the advantage and benefit of operating within the Boston/New England area, the second largest market behind the New York area. This location allows the Boston Red Sox to reach a large amount of people. Because of this, the Boston Red Sox sell out their tickets every game. According to Forbes Magazine, the Red Sox make their largest profit from their market size, which accounts for 43% of their team value. Along with the Boston market, the recent acquisition of pitcher Daisuke Matsuzaka has allowed the Red Sox to break into the Japanese market, giving them an entirely new level of revenue. Financial Position: Forbes Magazine has the Boston Red Sox ranked as Major League Baseball’s #3 most valuable team. According to Forbes, the Red Sox are valued at $724 million, a substantial increase since their 2002 acquisition, which had them valued at $380 million. Based on these rankings, the Red Sox have an operating income of $19.5 million, a sizeable increase from their 2006 operating income of -$18.5 million. Because of Major League Baseball’s inability to produce a salary cap, the Red Sox are able to use their extensive revenue to purchase players and put anShow MoreRelatedAdidas Group Is a Global Leader6231 Words   |  25 PagesRecently , Adidas Group is a global leader in the sporting goods industry and offers a broad portfolio of product Products from the adidas Group are available in virtually every country of the world . the adidas Group has been part of the world of sports on every level, delivering state-of-the-art sports footwear, apparel and accessories Our strategy is simple: continuously strengthen our brands and products to improve our competitive position and financial performance Adidas is on the move andRead MoreWine Consumption Essay examples6888 Words   |  28 PagesSouthern Peninsula Wines Content 1. Organisation overview a. 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Mid Term Exam Political Sciences - 1307 Words

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Research Essay Animal Law

Question: Describe the status of animals under the law and allow them to demonstrate their ability to explain, differentiate, critique and apply the major philosophical debates relating to animals and the law? Answer: Introduction The treatment made by human being to any species, is a matter which is having immense importance in recent times .There is a famous book which was published in the year 1975, called Animal Liberation, and this publication had brought huge reciprocation in Australia, as the people are imposed to think deliberately to take this cruel ministrations to animals on hold (Chandra, 2013). The government of United States also performed a pledge to protect their animals and created ninety animal law courses for the universities to conduct awareness through education. The provenance of Australia did not contribute much as compared to United States, as the latter one rose significantly in the scholarly literature on animals, whereas the legal academy of Australia has less inclination on this indispensable subject (Agoramoorthy, 2009). Still Australia had made pivotal move to bestow strong legal scholarship in animal law in many categories, such as territories, commonwealth and states, to monitor animal prosperity and equally entrusting their focus on farming animals and arranging systematic analyzing board. People have taken significant responsibility to get them into right shelter and to protect them from plastics (Chandra, 2013). The abolition on exploitation of animals for the interest of humans is certainly a topic to be discussed for the awareness of the true idea human interest over animal interest. That is the very reason of forming more wildlife sanctuaries. Status of animals under the law: The states and the territories of Australia has the power to regulate the animal welfare. Though, it is merely mentioned in the constitution of Australia regarding their common wealth role and its significance (Jordan and Kellogg, 1907) but every time, the commonwealth got entrusted with the responsibilities on regulating animal laws and that shows the Australian government should enhance their constitution by adopting more rules for providing animals in more protective sheds. In the year 1837, the Australia had got its first anti-cruelty legislation which was validated in Van Diemans land, continued in New South Wales, which was included in the legislation in 1850. All these legislations had not got the idea to provide sanity to animals and was therefore labeled as an offence especially if any individual would be found guilty of harsh treatment to animals, he shall be punished as per their criminal laws (Leavitt, 1990). So it is clear that the law initially was not based on the foundation as it did not have particular validation on the protection of natural resources. The 1848 revolt in Europe had raised an issue on sufferance of universe, targeting the lower class society in the offence of killing animals. Therefore, for not having a separate law for the welfare of animals, legislature had involved many anti-cruelty legislations pertaining to criminal laws (Short, 2007). In police Acts, the government of Australia had introduced new legislation for the p rotecting animals, in 1860s. Some customs which were predominant before 20th century have been considered devilish activities of human to animals. There were also some practices which involved business and some are for cultural diabolic, they are from killing of animals to branding, dehorning of castles, spaying, castration and, ear-splitting. The era of 1970s and 1980s, had shown some important exclusion from all these evil practices (White, 2012). The Animal care and protection act 2001 has brilliantly demonstrated that the harsh treatment on animals which includes unreasonable pain, circumstances which are unjustified and deformed carcass are legally taken into consideration which at the end of the day is criminal offence to a life. The enforcement laws, regarding animal welfare is having variation from States to territories. The regulatory methods of Australian authority have three standards of agents, and they are as follows: a departmental authority, the police and the royal society, all based for the Prev ention of Cruelty of Animals ('RSPCA'). But the responsibility of the police services is limited as they do not entrust much to get general duty on animal laws (Harrop, 2011). They only get a very small unit to investigate the offences concerning cruelty on animals, unlike United Kingdom; police administration has got severe responsibilities to take charge on animal laws as their introduction of various laws on the favor of animals make them strong enough to dealt with any given cases. The RSPCA has divided some jurisdictions to different roles for getting effective enforcement. In one of the example cited here by RSPCA is, in Queensland, the Department of Primary Industries and Fisheries have specific agreement to get easy access for understanding. With the joint collaboration of RSPCA and DPIF, they have introduced a MOU, a subject which enforces different Acts to different locations with expert opinions. Animals as property: The law that exists in New South Wales is basically known or referred to as the prevention of cruelty To Animals Act 1979.According to this law a person is not entitled to any action of cruelty towards the animal. Often the defense against this act that has countered the law on many instances has been under section s 24(1)(b)(ii) according to which the person charged with the offence will not be guilty if the animal is destroyed with the purpose of food for the consumption of human beings in a manner that is devoid of inflicting no more pain than is necessary towards the aforesaid animal. Property has no reference to a thing in particular instead it is an implication of the legal relationship that is existential as a law often referred to as a bundle of rights. The idea that exists pertaining to animal law basically overlooks the fundamental rights of animals when any conflicting human interests are found to exist. The owner of the animals always is given the upper hand when his interests are pitted against the animal so far as benefits are concerned. If there happens to be some proven and justified form of excess exploitation then only the interests of animals are observed. The law and legal system of the most of the western countries are primarily based on the culprit in proving the overall exploitation of the non-human, common law and civil law tradition plays a dualistic role which help to divide the non-human into two distinct normative entities that are person and things. Animal are treated as the thing and more precisely as the property of the individual. Animal laws related to the legal relation in the current law exist among the people. It is evident that there cannot exist a relationship between the thing and person. The status of the animal as property is based on the limited type of the legal protection which is increased to non-human. Under the current law of animal continue to be regarded as item of property, they are included as under the definition of the right for the purpose of the Australian consumer law consumer Guarantees regime nd are interpreted as the proper for the purpose.This is mainly so because in accordance with Yanner v/s e aton(1999), a property happens to exist to serve for a purpose and the laws are made under the assumption that the animals will not be harmed or inflicted more suffering than is necessary mainly because of the fact that excess exploitation of animals will only reduce their lifetime together with quality and value which is a direct loss for the property owner. The rights of the owners of property which in this case are animals itself are considered if any third party is found to infringe this legal binding and harm the animals. Overview of different theoretical and philosophical positions relating to animals and law: Animal rights refer to the legal rights those are entitled to the possession of the non-human animals (Arntzenius, 2014). Animal rights are entitled to the fulfillment of the basic interests of the animals ensuring avoidance of suffering. Animal law is taught in most of the schools of Australia. However, critics argue that the animals are incapable of entering into the social contracts. Utilitarianism is a theory that has been entitled to secure the interests of the animals. In animal liberation, it has been mentioned in the law that it is essential to consider the interests of the animals seriously. In other words, it has been argued that the human beings have been failed to consider the interests of the animals at large. It is evident from Singers theory of Utilitarianism, that When people seek to justify the horrific way in which animals are treated, they invariably point to supposed animal defects such as the inability of the animals to utilize human language or to reason as intr icately as human beings do. However, this particular law or legal right entails that human beings should give prior importance and equal importance to the animals. Singers theory is more applicable in case of animals than classical animal welfare. Utilitarianism engages the theories in normative ethics that hold proper course of action that maximizes the utility.It is evident that human beings have been failed to give prior importance to the animals just because of specific bias or specialism (Chandra, 2013). The concept of speciesism results into actual devaluation of the interests of the animals. According to Singer, the notion of equal treatment does not mean that animals receive equal treatment, and it does not preclude the morality of decisions to exploit a human or nonhuman. However, with the passage of time, Australia has been entitled to law of Animal Rights and Rescue management of animals. It is evident that the Animal Rights and the Rescue group of Australia carry out the procedures of rescue management of the unwanted and homeless animals. This particular group ensures the right of equal Consideration for the street animals and also provides shelter and care facilities for these animals. It is evident from the certain news reports and articles that The Australian Constitutionemphasizes on the animals rights so as to give emphasis on the procedures of animal welfare. It is evident that the standard regulatory approach is deficient in number of cases in Australia (Gibbard, 1984). The Australian anti-cruelty legislation was enacted in the year 1837. This particular entails the consideration of the animal cruelty offences in the criminal laws of Australia. Current Regulatory Paradigm: With respect to the theories of Australian philosopher Peter Singers book Animal Liberation, it has been articulated that the lives of the animals are of less importance than the lives of human beings. However, the paradigm lies in the fact that many Australian citizens take into consideration that current animal laws prevailing in Australia ensures animals with adequate protection from human mistreatment, cruel behavior from human beings (JihanLyou, 2008). However, it has been envisaged that the current regulatory framework could be improved. Thus, in order to improve the condition of the animals in Australia, certain legal acts have been enacted. These are as follows: The regulation of companion animals. Dog control legislation. The use of codes of welfare. Australias new regulatory regime for live exports. Animal welfare centers over the physical and the psychological wellbeing of the animals in order to maintain the animal ethics. The Australian Constitution considers that the animals do have a moral right. According to Kantian Theories, it is evident that both animals and humans have desires that can compel them to action but only humans are capable of standing back from their desires and choosing which course of action to take.Animals are not autonomous as they are incapable of expressing their will and ability(Pezet, 2014). Therefore, according to Kant, animals do not have intrinsic value. According to Singers theories, it has been argued that every animal should get equal consideration and equal interests. It can be contradicted that, somehow plants, animals and human beings are able to take nutrition. But only animals and human beings are having the ability of consciousness. This signifies that plants are inferior to the animals and human rights. Likewise, it can be contrasted th at human beings are more and more superior to that of animals and plants as human beings do have the capability of using logics and justification to their conduct whereas animals lack this particular characteristic. So they are often mistreated. It is evident from certain reports and articles that animals lack rationality. Contractualism however provides a view about the assessment of correctness and wrongness of the conduct of human beings towards the animals (Arntzenius, 2014). It is evaluated in certain theories of animal rights that social contracts can only be practiced or taken into consideration by rational persons and those human beings who have moral choice. However, moral choice excludes the consideration of animals into account (Harrop, 2011). Hence, with the implementation and the enactment of legal rights and norms it has been observed that appropriate actions includes morality and right actions are those which enables the assurance of maximization of the pleasure and minimization of the pain. However, as discussed above it is reflected from the classical Utilitarian theories that human beings feel superior to that of animals, so they find pleasure in killing and affecting animals to a large extent. They find pleasure in exploiting animals for food, clothing, and entertainment, which in turn affect the interests and the rights of the animals (Short, 2007). Therefore, the paradigm lie the fact that animals also have some level of moral values those need to be taken into consideration before affecting the animals in Australia as well as other parts of the world. Preference Utilitarianism: To shed light on the fact that utilitarianism is of vital importance, preference utilitarianism is to be taken into consideration. Preference utilitarianism is basically a concept in contemporary philosophy. The concept of preference utilitarianism differs from that of the classical utilitarianism. The concept of preference utilitarianism entails the promotion of the actions with the view of fulfilling the interests of both human beings as well as animals as concerned. According to Bentham, every human being must have a sense of shared sentience which reflects the overview about the sense of equal consideration for both human beings as well as the animals as well (Pezet, 2014). Equal consideration is a concept that the Australian Constitution enacted in order to give equivalent importance to the animals so as the human beings (Short, 2007). But on the contrary, the concept of equal consideration does not take into account a great degree of precision as presently, the utilitarian calc ulus is trying to maintain a specific level of balance between the minor interests of the human with that of the major interests of animals which centers the aspects of not suffering from the mistreatment from the human beings. Apart from this concept, preference utilitarianism entails that it is justifiable to utilize animals on a wider extent than of human beings. This is so because human beings do have the advanced mental capacity which the animals do not have (Sidgwick, 2000). So it is beneficial to use animals than that of human beings. In other words, Abolishing the property status of animals is therefore a strong focus of attention for many animal protection scholars. It is found in Australia, that people have chosen the way consuming milk from different sources other than animal sources. This signifies that there had been a wider scope of growth in the demand of meat over the few decades. Therefore, it is worthwhile that preference should be given in order to alleviate the s ufferings of the animals to a wider context (Harrop, 2011). According to the Australian philosopher, it has been observed that the interests of the animals are the same so as the interests of the human beings. He has given emphasis on the principles of equal consideration so as vegetarianism which includes factory farming and fur farming. Critique of Utilitarianism: From the above context, it is made clear that animals should not be made to suffer without any cause or reason. This should be the moral value and the principle of the human beings towards the animals. The concept of utilitarianism entails that every human being must look after the maximization of the pleasure and minimization of the pain (Williams, 2004). Therefore, consuming animal meat is against the law. 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